Analysis of eight glycols in serum using LC-ESI-MS-MS.
Identifieur interne : 003334 ( Main/Exploration ); précédent : 003333; suivant : 003335Analysis of eight glycols in serum using LC-ESI-MS-MS.
Auteurs : Laurent Imbert [France] ; Elodie Saussereau [France] ; Christian Lacroix [France]Source :
- Journal of analytical toxicology [ 1945-2403 ]
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Butylene Glycols, Ethylene Glycol, Ethylene Glycols, Glycols, Propylene Glycols.
- chemical , metabolism : Polyethylene Glycols.
- methods : Chromatography, Liquid, Tandem Mass Spectrometry.
- Humans, Limit of Detection, Reproducibility of Results.
Abstract
A liquid chromatography coupled with electrospray tandem mass spectrometry method was developed for the analysis of ethylene glycol, diethylene glycol, triethylene glycol, 1,4-butanediol, 1,2-butanediol, 2,3-butanediol, 1,2-propanediol and 1,3-propanediol, in serum after a Schotten-Baumann derivatization by benzoyl chloride. Usual validation parameters were tested: linearity, repeatability and intermediate precision, limits of detection and quantification, carry over and ion suppression. Limits of detection were between 0.18 and 1.1 mg/L, and limits of quantification were between 0.4 and 2.3 mg/L. Separation of isomers was possible either chromatographically or by selecting specific multiple reaction monitoring transitions. This method could be a useful tool in case of suspected intoxication with antifreeze agents, solvents, dietary supplements or some medical drug compounds.
DOI: 10.1093/jat/bku100
PubMed: 25187402
Affiliations:
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last="Saussereau">Elodie Saussereau</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacokinetic and Toxicology Unit, Hospital Group of Le Havre, BP 24, 76083 Le Havre cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacokinetic and Toxicology Unit, Hospital Group of Le Havre, BP 24, 76083 Le Havre cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Lacroix, Christian" sort="Lacroix, Christian" uniqKey="Lacroix C" first="Christian" last="Lacroix">Christian Lacroix</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacokinetic and Toxicology Unit, Hospital Group of Le Havre, BP 24, 76083 Le Havre cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacokinetic and Toxicology Unit, Hospital Group 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Glycols</term><term>Ethylene Glycol</term><term>Ethylene Glycols</term><term>Glycols</term><term>Propylene Glycols</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Polyethylene Glycols</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, Liquid</term><term>Tandem Mass Spectrometry</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Limit of Detection</term><term>Reproducibility of Results</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A liquid chromatography coupled with electrospray tandem mass spectrometry method was developed for the analysis of ethylene glycol, diethylene glycol, triethylene glycol, 1,4-butanediol, 1,2-butanediol, 2,3-butanediol, 1,2-propanediol and 1,3-propanediol, in serum after a Schotten-Baumann derivatization by benzoyl chloride. Usual validation parameters were tested: linearity, repeatability and intermediate precision, limits of detection and quantification, carry over and ion suppression. Limits of detection were between 0.18 and 1.1 mg/L, and limits of quantification were between 0.4 and 2.3 mg/L. Separation of isomers was possible either chromatographically or by selecting specific multiple reaction monitoring transitions. This method could be a useful tool in case of suspected intoxication with antifreeze agents, solvents, dietary supplements or some medical drug compounds.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li></settlement></list><tree><country name="France"><region name="Région Normandie"><name sortKey="Imbert, Laurent" sort="Imbert, Laurent" uniqKey="Imbert L" first="Laurent" last="Imbert">Laurent Imbert</name></region><name sortKey="Lacroix, Christian" sort="Lacroix, Christian" uniqKey="Lacroix C" first="Christian" last="Lacroix">Christian Lacroix</name><name sortKey="Saussereau, Elodie" sort="Saussereau, Elodie" uniqKey="Saussereau E" first="Elodie" last="Saussereau">Elodie Saussereau</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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